Find out what a flight from Chicago O'Hare to Santa Cruz de la Sierra might cost

Prices vary based on date, airline, and availability. Compare several options if you're flying between Chicago and Santa Cruz.

Select your dates to check current offers.

Try shifting your departure forward or backward by a day to find better options. If you’re looking for a good deal, consider flying outside peak hours as well.

Which airports are most convenient between Chicago and Santa Cruz?

Whether it’s cost or connection time, the right airport combination can make a difference.

• Airports in Chicago: There are 3 airports in Chicago - Midway, O'Hare, Rockford.
• Airports in Santa Cruz: Santa Cruz is also worth considering.

In some cases, flying into a secondary airport can also reduce transfer costs. Connections from multiple airports give you more flight options and airlines.

Flight filters for the route Chicago O'Hare – Santa Cruz de la Sierra

Customize your search on Jetcost to focus only on flights that suit your needs. Whether you want a direct connection, specific airline, or shorter layover, filters help you find it faster.

Other popular destinations

Flights to Bolivia are often searched alongside: Cochabamba, La Paz, Quijarro, Santa Cruz, Tarija.

The cheapest flights might leave at odd hours or arrive at less central airports — keep that in mind. If you travel often, you can always select your trusted airlines from the available options.