Cheap flights from Mayaguez to Panama City

Flights tailored to your budget

Selected dates may not give results due to COVID-19. We suggest you change the dates.
Multi-city Round trip One way
Round trip
One way
Multi-city
From
No results match your search criteria
To
No results match your search criteria
{{ weekDay }}
Dates
{{ panel.label }}
Looking for a one-way flight?

Flexible dates can save you money

Explore nearby dates to find lower fares

{{ fromDate | dateToLongNamedDate }}
?
Flexible dates
Depart {{ flexibleFromDateLabel }}
{{ option.label }}
?
Return {{ flexibleToDateLabel }}
{{ option.label }}
Passengers / Class
Number of passengers
Adult
{{ adults }}
Children
{{ children }}
Infants
{{ infants }}
Class
Economy
Available for Economy only
New Multi-city experience

Discover a new Multi-city search experience from Jetcost, designed to handle more complex itineraries. By continuing, you’ll be taken to a dedicated page powered by Kiwi.com.
How do we get the info you see here? Please note that we offer an online comparison service and that all information and prices regarding services and/or products available on our website are provided by our third-party partners. We do our best to show you up-to-date information, but please note that we are not responsible for the completeness or accuracy of the information published, so please check all conditions carefully on the website of the partner before making a booking. Please check our Terms and Conditions for more details. Read more

Planning a flight from Mayaguez to Panama City?

Flight prices from Mayaguez to Panama City change depending on demand and time of booking.

Choose a date to explore the best fares now.

Many users find better fares by booking several weeks in advance. In fact, for many routes, booking early is one of the best ways to save.

Are there multiple airports in Mayaguez and Panama City?

If your departure or arrival city has more than one airport, it's worth comparing all of them for timing and pricing.

  • Airports in Mayaguez: Only Mayaguez - Eugenio Maria de Hostos operates in this city.
  • Airports in Panama City: 2 airports are available in Panama City - Pacífico International Airport, Paitilla.

If you're traveling with a group or bulky luggage, look into parking or transport options. Alternative airports may offer faster transfers or better rates.

Flights from Mayaguez - Eugenio Maria de Hostos to Panama City - Tocumen

Plan your journey from Mayaguez to Panama City with ease

Use Jetcost to tailor your search — direct or connecting flights, round-trip or one-way, filtered by airline, price, travel time, or agency.

Other popular destinations

Exploring options in Panama? These cities are trending: Bocas Del Toro, Changuinola, David, Panama City, Puerto Obaldia.

Flight availability can change quickly — refresh the results if you’ve been away from the page for a while.
Frequently Asked Questions

Frequently asked questions about flights from Mayaguez to Panama City.

How much does an airline ticket from Mayaguez to Panama City cost?

Flight prices can vary a lot depending on the period and destination. At the moment, this information is not available for flights from Mayaguez to Panama City.

How far is Mayaguez from Panama City?

Mayaguez is about 1668 km from Panama City.

What are the airports in Panama City?

Panama City has 2 airports: Pacífico International Airport, Paitilla.

What are the airports in Mayaguez?

Mayaguez has one airport: Mayaguez - Eugenio Maria de Hostos.

What are the most popular cities in Panama?

The most popular cities in Panama according to our users' searches are: Bocas Del Toro, Changuinola, David, Panama City, Puerto Obaldia.

When should I book a flight from Mayaguez to Panama City?

This information is not available at the moment.

What is the cheapest month to fly from Mayaguez to Panama City?

This information is not available at the moment.

What is the most expensive month to fly from Mayaguez to Panama City?

This information is not available at the moment.

What is the best day of the week to fly from Mayaguez to Panama City?

This information is not available at the moment.