How much is a flight from Panama City to Santo Domingo La Isabela?

Prices vary based on date, airline, and availability. Compare several options if you're flying between Panama City and Santo Domingo.

Pick a travel date to see today’s available fares.

Fares change often — checking several times throughout the week can make a big difference. Booking in advance often means access to lower prices for the Panama City - Santo Domingo La Isabela route.

Planning flights between Panama City and Santo Domingo? Don’t forget the airport options

Especially when flying to medium or large cities, it's worth checking all possible airport combinations before booking.

• Airports in Panama City: 2 airports are listed in Panama City - Pacífico International Airport, Paitilla.
• Airports in Santo Domingo: Only Santo Domingo - La Isabela is currently available.

Check for differences in transport costs to and from each airport — they affect your total spend. Choosing the right airport can make a real difference in price and timing.

Plan your journey from Panama City to Santo Domingo La Isabela with ease

Use Jetcost to tailor your search — direct or connecting flights, round-trip or one-way, filtered by airline, price, travel time, or agency.

Other popular destinations

Exploring options in Dominican Republic? These cities are trending: La Romana, Puerto Plata, Punta Cana, Santiago, Santo Domingo.

Flight availability can change quickly — refresh the results if you’ve been away from the page for a while.